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Letters
To the Editor: We are writing in response to the editorial of Ben-Tovim et al.1 Although we agree that more research into treatment efficacy in eating disorders is needed, we believe that the study to which reference is made2 is seriously flawed. The study should not be presumed to provide evidence about the effect of treatment on outcome, particularly as the majority of patients studied received no treatment. The high death rate (3/95 [3.2%] among patients with anorexia nervosa and 2/37 [5.4%] among patients with "eating disorders not otherwise specified") in such mildly ill patients (few of whom would have warranted hospitalisation on the basis of their weight) approximates that of seriously emaciated patients in longer-term studies of treatment outcome3,4 and could more properly be said to illustrate the results of having no treatment or inadequate treatment.
Exactly what constituted specialised treatment is never actually described in the original article,2 in which "extended inpatient treatment" is defined as treatment lasting more than two weeks and "extended outpatient treatment" as three or more visits. Thus, the so-called "resource intensive treatment" the authors refer to would not necessarily represent even adequate management of these conditions.
In our own 6–10-year outcome study5,6 cited by the authors, 61 emaciated patients with anorexia nervosa received, on average, 11 weeks of inpatient treatment consisting of nutritional rehabilitation and psychotherapy. Only one patient died (of suicide) and, of the patients fully assessed, 41/50 (82%) had a good or intermediate outcome. The degree of weight restoration achieved by the end of treatment correlated with the degree of osteoporosis 10 years later.7
In other studies, duration of illness and early intervention have been shown to significantly influence outcome.4 This contrasts with the findings of Ben-Tovim et al,2 which may have been skewed by an unusual level of chronicity in the study group. A recent study of 69 patients with eating disorders treated in our own multidisciplinary program showed that, on 12–18-month follow-up, 48/69 (70%) had improved and 34/69 (49%) no longer had an eating disorder diagnosis. Mean levels of all but one of the major behavioural and psychological features rated by the EEE-C (Eating and Exercise Examination by Computer) instrument8 were significantly reduced.
The advice given by Ben-Tovim and colleagues to the parents of the hypothetical 15-year-old girl with anorexia nervosa is regrettably nihilistic and, if based on their Lancet study,2 not founded on sound or generalisable evidence. Parents should be referred to a program for which good outcomes have been demonstrated, treatment accords with published guidelines, the clinicians are suitably experienced, and in which early intervention is the aim.4
(Received 19 Sep 2001, accepted 31 Oct 2001)
Eating Disorders Program, Northside Clinic, Greenwich, NSW.
Janice D Russell, MD FRACP FRANZCP, Director; and Clinical Associate Professor, Department of Psychological Medicine, University of Sydney; Suzanne F Abraham, PhD, Codirector; and Associate Professor, Department of Reproductive Medicine, University of Sydney.Correspondence: Associate Professor Janice D Russell, Eating Disorders Program, Northside Clinic, 2 Greenwich Road, Greenwich, NSW 2065. jrussel1ATmail.usyd.au
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In reply: The commitment of Russell and Abraham to their own program has distracted them from accurate reporting and sound epidemiological principles. They say that the majority of patients that we studied received no treatment. Not so. We clearly stated that only 34 of the 220 patients studied received no treatment.1 They then draw a range of inferences from the fact that "3/95 (3.2%)" patients with anorexia nervosa died. In fact, only 2 of 95 patients with anorexia nervosa died as a consequence of that disorder during the five years of our study. At 2.1%, this is similar to the crude death rate of 1/61 (1.6%) that they describe in their own study.
However, it is only acceptable to use a rare outcome as a measure of the efficacy of a treatment program if the clinical characteristics that put patients at risk for such an outcome are known and accounted for. We do not know the specific factors that put people at particular risk of dying from anorexia nervosa. Without such knowledge, small differences in crude death rates can not of themselves inform us whether treatment programs diminish or accentuate such risks. Unfortunately, there are no other studies against which to compare the outcomes of the patients with "eating disorders not otherwise specified" in our study. We have dealt with issues such as the representative nature of our study elsewhere.2 I stand by our work and the conclusions we draw from it.
Flinders Medical Centre, Bedford Park, SA.
David I Ben-Tovim, PhD FRANZCP, Director, Clinical Epidemiology Unit, and Associate Professor of Psychiatry.Correspondence: Associate Professor David I Ben-Tovim, Flinders Medical Centre, Flinders Drive, Bedford Park, SA 5042. David.Ben-TovimATfmc.sa.gov.au
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©The Medical Journal of Australia 2002 www.mja.com.au PRINT ISSN: 0025-729X ONLINE ISSN: 1326-5377