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The Weight Debate

What should we do about overweight and obesity?

The goals of treatment should not necessarily be to normalise weight, but to optimise health

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MJA 1999; 171: 599-600

Introduction - Why are we getting obese? - Why have we not been effective in treating obesity? - What should we do about obesity? - What has been ignored is our environment
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Introduction Obesity and overweight have always been with us, but they are now the norm rather than the exception. Almost two-thirds of Australian men and about half of Australian women are overweight (body mass index [BMI] 25-29.9) or obese (BMI Greater than or equal 30).1 Obesity in Australian children appears to have doubled in recent years.1 Increasing obesity is a worldwide phenomenon,2 and with it comes an increase in obesity-related metabolic disease, such as type 2 diabetes, dyslipidaemia, hypertension and ischaemic heart disease. In Australia the health costs of obesity and its associated diseases have been estimated to be some $830 million.3 This figure ignores the intangible costs due to premature death, the effects of obesity on quality of life and the amount spent on weight loss programs (more than $500 million).



Why are we getting obese?
In this issue of the Journal, several articles allude to contributing causes: the genetic basis of obesity, (over)abundance of food, and our technological society with its emphasis on labour-saving devices, efficiency and time saving. We are less active in our everyday lives; it is not just that we are not exercising, but that the incidental activity of everyday life has been reduced or eliminated by technological advances. We don't walk as much, or as far, and we don't expend as much energy operating machinery or manual tools. Consequently, it has proved very difficult for many people to control their weight in the second half of the 20th century.



Why have we not been effective in treating obesity?
There are a number of reasons for this. Obesity, its aetiology and effects, the biology of adipose tissue (which is not just an inert storage organ) and goals of treatment have been poorly understood. Nutrition has not been considered an important part of the medical curriculum. No long term effective medical treatments have been available. Finally, as Dupen et al show, only 6% of the articles in medical publications discuss physical activity,4 so it is little wonder that this effective medical and public health approach is ignored in favour of other programs or pharmacological therapy. Governments, our own included, are now promoting greater physical activity because of the impact of sedentary lifestyle on health.5,6

Despite the lack of real assistance from the medical profession, the obese have been stigmatised.7 Obese patients have become disheartened after their attempts at weight loss. They have turned to other treatments and therapists, mostly without success. The results of therapy with some of the more recent, and less outlandish, therapies are reviewed by Egger et al 8 in this issue of the Journal. The vast majority of these treatments, some costly, are ineffective. Patients are still looking for the magic which will enable them to lose weight without effort and then to keep it off.



What should we do about obesity?
Two major options are discussed in articles in this issue of the Journal. Burry argues that weight loss and control must remain an individual responsibility,9 whereas Proietto argues that in some individuals morbid obesity is inevitable because of their genes, inherent appetite drives and metabolic setpoints, and that they will inevitably need pharmacological help to control weight.10

These are not really exclusive categories; both approaches are correct in part and do have a place. Some individuals with higher BMIs (possibly > 35) will have genetic causes of their obesity; some of those who are overweight should be able to control their weight by taking responsibility for their lifestyle; but there are also those who need both lifestyle alteration and adjunctive therapy. Medical practitioners must judge what combination of therapy and behavioural change would benefit each patient. A supportive, knowledgeable medical environment in which individuals can be helped to understand what is necessary in the way of food intake and daily activity is vital. When lifestyle changes are not enough, or in the presence of metabolic disease, an appropriate medical treatment should be added.2

The goals of such treatment should not necessarily be to normalise body weight, but to optimise health. A reduction of 6-10 kg can significantly decrease the cardiovascular health risks of overweight or obese people.11 There are new drugs which capitalise on the increasing knowledge of the physiology and pathophysiology of body weight and which help achieve and maintain this degree of weight loss. Two available outside Australia are orlistat, a pancreatic lipase inhibitor which reduces fat absorption by 30%,12 and sibutramine, which has both noradrenergic and serotonergic effects acting on appetite and thermogenesis.13 Some of the other drugs in development that may alter energy expenditure or central appetite control pathways include leptin derivatives, thermogenic agents and neuropeptide Y antagonists.



What has been ignored is our environment
We accept that we can change the environment when (for example) building developments, second airports, smoking and recycling are concerned, but we abrogate responsibility for many healthy lifestyle issues, including the prevention of obesity. The recent increase in obesity can be attributed to environmental change, as our genes haven't changed. Therefore, we need to change our environment to prevent obesity.

Health education alone hasn't been enough to impede the increase in obesity. We can make it easier and safer for Australians to be more active. We can ensure that all Australians get access to cheap, fresh, healthy foods. We can ensure our children have the opportunity to be fit and healthy. The type of environmental change necessary is not the "micro-environmental" change by individuals or in homes, but rather "macro-environmental" changes which involve governments, policies, planning, business and health professionals.14 Such changes involve urban planning, transport, roads, and food production and distribution. Workplaces and schools must be involved. We need to plan for a healthy environment that encourages and makes activity possible and which delivers cheap, healthy food to all.

It is important to make a distinction in types of activity. While some may choose to become physically active (eg, jog, or play sport) what we wish to encourage and increase is "incidental activity". This means more activity in our daily lives, coupled with opportunity to do even more physical activity by individual choice. Examples might be providing bike tracks, or measures to increase the amount of walking required by commuters (by moving car parks, increasing the use of public transport, or replacing lifts and escalators with ramps and stairs). We may need to look critically at some labour-saving devices and promote the health benefits of manually powered devices.

The aim is not to make everyone thin, but to prevent some becoming overweight or obese. A mean weight loss of 1 kg in the Australian population would have a major impact on health. We actually have a plan to attempt this.3 It requires intersectoral cooperation between government departments (not just health departments), non-government organisations, local government, health professionals and the community.

Rather than insisting that weight control is an individual responsibility, medical practitioners can take the lead in altering the environment and educating and involving those who can.

Ian D Caterson
Human Nutrition Unit, Department of Biochemistry
University of Sydney, NSW

Reprints: Professor I D Caterson, Department of Biochemistry GO8, University of Sydney, NSW 2006.

Statement of conflict of interest: Ian Caterson chairs the National Obesity Prevention Group of the Commonwealth Department of Health and Aged Care. He has received funds for research studies and trials, or for advice about obesity, from Servier Laboratories, Roche Products, Knoll Australia, 3M Pharmaceuticals and the World Health Organization.

  1. McLennan W, Podger A. National Nutrition Survey -- Selected Highlights Australia. Canberra: Australian Bureau of Statistics and Department of Health and Family Services, 1997.
  2. Obesity: preventing and managing the global epidemic. Report of a WHO consultation on obesity, Geneva, 3-5 June, 1997. WHO: Geneva, 1997.
  3. National Health and Medical Research Council. Acting on Australia's weight. The Report of the NHMRC Working Party on the prevention of overweight and obesity. Canberra: NHMRC, 1996.
  4. Dupen F, Bauman A, Lin R. The source of risk factor information for general practitioners: is physical activity under-recognised? Med J Aust 1999; 171: 601-603.
  5. Physical activity and health: a report of the Surgeon General. Atlanta, Md: US Department of Health and Human Services, Centers for Disease Control, 1996.
  6. National Physical Activity Guidelines for Australians. Canberra: Commonwealth Department of Health and Aged Care, 1999.
  7. Wing RR, Greeno CG. Behavioural and psychosocial aspects of obesity. Clin Endocrinol Metab 1994; 8: 689-703.
  8. Egger G, Cameron-Smith D, Stanton R. The effectiveness of popular, non- prescription weight loss supplements. Med J Aust 1999; 171: 604-608.
  9. Burry JN. Obesity and virtue. Is staying lean a matter of ethics? Med J Aust 1999; 171: 609-610.
  10. Proietto J. Why staying lean is not a matter of ethics. Med J Aust 1999; 171: 611-613.
  11. Goldstein DJ. Beneficial health effects of modest weight loss. Int J Obes 1991; 16: 397-415.
  12. Sjostrom L, Rissanen A, Andersen T, et al. Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. Lancet 1998; 352: 167-172.
  13. McNeely W, Goa KL. Sibutramine. A review of its contribution to management. Drugs 1998; 56: 1093-1124.
  14. Egger G, Swinburn B. An "ecological" approach to the obesity pandemic. BMJ 1997; 315: 477-480.

©MJA 1999
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