- Genetic sequencing of the myeloma genome has not revealed a specific disease‐determining genetic alteration.
- Multiple disease subclones exist at diagnosis and vary in clinical importance with time and drug sensitivity.
- New diagnostic criteria have identified indications for early introduction of therapy.
- Autologous stem cell transplantation remains an essential component of therapy in young and fit patients.
- The use of continual suppressive (maintenance) therapy has been established as an important component in therapy.
- Immune therapies and the harnessing of the innate immune system offer great promise for future treatments.
- Since 2005, quality of life, supportive therapies, and survival have dramatically improved over a decade of remarkable progress.
- The common manifestations of multiple myeloma, such as bone pain, fatigue and weight loss, may be non‐specific and are often initially ignored or missed by patients and medical practitioners.
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