Short course 6.8
Benzodiazepines
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© 1998 MJA
| Buspirone, an alternative to benzodiazepines
| Buspirone acts by different pharmacological pathways to the benzodiazepines, and does not present the same problems with dependence. |
| | Buspirone is as effective as the benzodiazepines for treating generalised anxiety disorder.
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| | Usual dose is 15-30 mg per day.
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| | Possible side effects (10% or fewer patients) are dizziness, drowsiness, nausea, headache, nervousness, fatigue and insomnia.
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| | Onset of action is gradual, with clinical improvement within 1-2 weeks increasing up to 6 weeks.
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| | Drug interactions are few, although the combination with a selective serotonin reuptake inhibitor may lead to serotonergic syndrome or worsening of anxiety symptoms. Buspirone should not be administered with monoamine oxidase inhibitors.
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