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Central nervous system depressants: Alcohol and most other anxiolytic and sedative-hypnotic drugs (i.e., barbiturates, benzodiazepines, meprobamate, methaqualone, glutethamide)
(Can produce physical dependence and tolerance).

Central nervous system stimulants: Cocaine, amphetamine, methamphetamine, dexamphetamine, methylphenidate, cathinone (khat), nicotine, caffeine, some anorectics (e.g., mazindol).
(Can produce physical dependence and tolerance).

Opioid (narcotic) analgesics: Heroin (diacetylmorphine), all painkillers other than those that are specifically anti-inflammatory (e.g., dextropropoxyphene, codeine, oxycodone, dextromoramide, buprenorphine, morphine, pethidine, methadone and fentanyl), some antitussives (e.g., hydrocodone, pholcodine), some antidiarrhoeal agents (e.g., diphenoxylate)
(Can produce physical dependence and tolerance).

Cannabinoids: Marijuana, hashish

Solvents: toluene, paint thinners, petrol, methanol, alcohol
(Alcohol, while acting as a central nervous system depressant, produces most of its toxicity because it is a solvent).

Psychedelics: LSD, mescaline, psilocybin, psilocin, dimethyltryptamine (DMT), dimethoxymethylamphetamine (DOM, or "STP")

"Designer" drugs: Dimethoxyamphetamine (DMA), phencyclidine (PCP, or "angel dust"), methylenedioxymethamphetamine (MDMA, or "ecstasy")
(These have both psychedelic and stimulant effects - i.e., they are both LSD-like and amphetamine-like).

Others: Antihistamines, anticholinergics, amyl nitrite, nitrous oxide, ethyl ether, nutmeg, bufotenine

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