4: Maternal and fetal outcomes in women with pre-eclampsia (mild and severe) according to antenatal hyperuricaemia, severe hypertension or proteinuria (see text for definitions). Data are percentages or means (standard deviation).
	Hyper-uricaemia	Normal uric acid	P	Severe hypertension	Mild hypertension	P	No proteinuria	Proteinuria	P
n	481	344		171	654		160	665
Age (years)	28 (5)	28 (5)	0.68	27 (5)	28 (5)	0.38	28 (5)	28 (5)	0.82
Nulliparae (%)	65	57	0.04	73	59	0.001*	68	60	0.09
Gestation at presentation (weeks)	36 (5)	35 (5)	0.30	35 (4)	35 (5)	0.58	34 (6)	36 (5)	0.001*
Gestation at delivery (weeks)	38 (2)	37 (3)	0.0001*	37 (3)	38 (2)	< 0.0001*	36 (4)	38 (2)	< 0.0001*
Hyperuricaemia (%)	--	--	76		54	< 0.0001*	79	53	< 0.0001*
Maternal complications
Severe hypertension	27%	12%	< 0.0001*	--	--		53%	13%	< 0.0001*
Thrombocytopenia	13%	6%	0.0015*	21%	7%	< 0.0001*	19%	8%	< 0.0001*
Proteinuria	26%	10%	< 0.0001*	50%	11%	< 0.0001*	--	--
Renal impairment	10%	2%	< 0.0001*	16%	5%	< 0.0001*	21%	1%	< 0.0001*
Liver disease	13%	5%	0.0002*	27%	5%	< 0.0001*	21%	7%	< 0.0001*
Neurological	17%	5%	< 0.0001*	36%	6%	< 0.0001*	33%	7%	< 0.0001*
Laboratory data
Plasma creatinine (mmol/L)	0.08 (0.04)	0.07 (0.02)	< 0.0001*	0.07 (0.02)	0.07 (0.04)	0.58	0.08 (0.07)	0.07 (0.02)	0.12
Plasma uric acid (mmol/L)	0.44 (0.19)	0.30 (0.04)	< 0.0001*	0.42 (0.08)	0.38 (0.18)	0.001*	0.42 (0.09)	0.38 (0.18)	< 0.0001*
Plasma albumin (g/L)	33 (5)	34 (5)	0.0003*	32 (6)	34 (5)	0.0001*	30 (7)	34 (4)	< 0.0001*
Haemoglobin (g/L)	119 (22)	121 (18)	0.11	118 (30)	121 (17)	0.25	115 (32)	122 (16)	0.014
Haematocrit (%)	35.1 (5.9)	35.8 (4.9)	0.09	34.7 (6.6)	35.6 (5.2)	0.13	33.9 (6.8)	35.8 (5.1)	0.003*
Platelets (x 109/L)	218 (83)	237 (78)	0.0011*	204 (84)	232 (80)	0.0001*	196 (79)	234 (81)	< 0.0001*
Fetal complications
SGA (%)	23	13	0.0008*	27	17	0.004*	24	17	0.044
PNM (per 1000)	15	9	0.45	29	8	0.02*	38	6	0.001*
Birthweight (g)	2902 (722)	3089 (663)	0.0002*	2585 (798)	3084 (634)	< 0.0001*	2498 (866)	3097 (601)	< 0.0001*
* Statistically significant (see text). SGA = small-for-gestational-age. PNM = perinatal mortality.

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