4:·Change in health and psychological rating scale scores (standard deviation)

	6 Month data (n=28)
	Entry	3 months	6 months	P (0-6)	P (3-6)
Physical Rating Scale	2.84 (1.3)	2.53 (1.5)	2.42 (0.8)	0.03	0.35
Brief Psychiatric Rating Scale	12.97 (10.34)	8.82 (8.2)	12.5 (11.6)	0.31	0.08

	12 Month data (n=20)
	Entry	6 months	12 months	P (0-12)	P (6-12)
Physical Rating Scale	2.86 (1.04)	2.2 (0.8)	1.9 (0.7)	0.00	0.14
Brief Psychiatric Rating Scale	13.45 (8.2)	9.9 (7.1)	8.65 (7.2)	0.02	0.18

N.B.
3 month data: Missing data for 9 patients, 8 discontinued treatment.
6 month data: Missing data for 12 patients, 18 discontinued treatment.
12 month data: Missing data for 13 patients, 25 discontinued treatment.