2:·Changes in opiate treatment index scores and the numbers of patients using illicit drugs

Mean opiate treatment index scores (SD)
12 Month data (n=32)
Entry	6 months	12 months	P (0-12)	P (6-12)
Number of drug classes used (polydrug use) in previous four weeks
4.17 (1.73)	3.04 (1.25)	2.69 (1.38)	0.0001	0.07
HIV risk behaviour (higher scores indicate higher levels of risk behaviour)
9.83 (5.65)	8.92 (5.14)	7.32 (3.54)	0.01	0.02
Illicit drug injecting risk behaviour subscore
5.76 (3.91)	1.0 (1.85)	0.32 (0.48)	0.0001	0.04
Sexual risk behaviour subscore
3.66 (4.17)	3.32 (3.26)	2.36 (2.65)	0.05	0.03
Social functioning (higher scores indicate poorer social functioning)
20 (5.97)	17 (4.27)	17.19 (4.71)	0.01	0.4
Criminal activity (higher scores indicate higher levels of criminal activity)
1.97 (2.2)	0.23 (0.82)	0.27 (0.87)	0.0001	0.28
General Health Questionnaire psychological adjustment (higher scores indicate higher levels of non-psychotic psychopathology)
10.28 (8.30)	4.96 (6.18)	4.35 (5.7)	0.0001	0.3
Health status (higher scores indicate poorer health)
14.59 (6.84)	10.23 (7.16)	9.04 (4.61)	0.0001	0.15

Number (%) of patients
3 Month data (n=49)			6 Month data (n=36)
Entry	3 months	P (0-3)	Entry	6 months	P (0-6)
Using illicit heroin
36 (73.5%)	13 (26.5%)	0.00001	28 (77.8%)	11 (30.6%)	0.0001
Using other opiates
20 (40.8%)	8 (16.3%)	0.01	14 (38.9%)	6 (16.7%)	0.07
Using tranquillisers
22 (44.9%)	10 (20.4%)	0.01	17 (47.2%)	6 (16.7%)	0.01
Using amphetamines
6 (12.2%)	1 (2.1%)	0.11	6 (16.7%)	1 (2.8%)	0.11
Using "crack"/cocaine
20 (40.8%)	11 (22.4%)	0.001	14 (38.9%)	4 (11.1%)	0.001

Number (%) of patients
12 Month data (n=32)
Entry	6 months	12 months	P (0-12)	P (6-12)
Using illicit heroin
25 (78.1%)	10 (31.3%)	9 (28.1%)	0.0001	1.0
Using other opiates
11 (34.4%)	6 (18.8%)	4 (12.5%)	0.05	0.23
Using tranquillisers
14 (43.8%)	4 (12.5%)	5 (15.6%)	0.01	0.31
Using amphetamines
2 (6.3%)	0	1 (3.1%)	1.0	1.0
Using "crack"/cocaine
15 (46.9%)	3 (9.4%)	6 (18.8%)	0.01	0.5

N.B.
3 month data: Missing data for 1 patient, 8 discontinued treatment.
6 month data: Missing data for 4 patients, 18 discontinued treatment.
12 month data: Missing data for 1 patient, 25 discontinued treatment.

*SD = standard deviation.