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Letters

Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin

Richard N Pearson
MJA 2009; 191 (7): 416

To the Editor: I read with interest the recent case report by Lim and colleagues on Chromobacterium violaceum endocarditis.1 References to the article do not include a report of a similar case published 20 years ago, also in the MJA.2 Perhaps reference searches can be enhanced — otherwise, identifying such similar cases falls to recollected experience (I was the initial treating doctor in the 1988 case) or an improbably capacious memory in the author or reader.

What saved the patient in February 19882 were two new antibiotics that were not generally available at the time but were held at Royal Brisbane Hospital — imipenem and ciprofloxacin. Imipenem is a β-lactam antibiotic of the carbapenem subgroup, derived from Streptomyces cattleya, that was developed in 1985.3 Imipenem and other carbapenems including meropenem, as used to treat the patient in the article by Lim et al,1 are now available in Australia but restricted to intravenous use in hospitals. The oral antibiotic ciprofloxacin became generally available with a Pharmaceutical Benefits Scheme authority benefit soon after the 1988 case.

I recall a discussion at that time with the late Dr Richard Kemp (then Director of Infectious Diseases at Royal Brisbane Hospital), who told me that C. violaceum infection in humans had been described in the world medical literature only about 10 times, and there had been no eventual survivors. From a general practitioner’s perspective, there was a lesson to be learned from the case: take the time to swab an abscess. The one in question was unusual — volcanic in appearance, indurated and not productive of pus on incision.

Richard N Pearson, General Practitioner

Medifirst Noosa Medical Centre, Noosa Heads, QLD.

richard.n.pearsonATgmail.com

  1. Lim IWM, Stride PJ, Horvath RL, et al. Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin. Med J Aust 2009; 190: 386-387. <eMJA full text> <PubMed>
  2. Georghiou PR, O’Kane GM, Siu S, Kemp RJ. Near-fatal septicaemia with Chromobacterium violaceum. Med J Aust 1989; 150: 720-721. <PubMed>
  3. Clissold SP, Todd PA, Campoli-Richards DM. Imipenem/cilastatin: a review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy. Drugs 1987; 33: 183-241. <PubMed>

(Received 14 Apr 2009, accepted 29 Jul 2009)


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©The Medical Journal of Australia 2009 www.mja.com.au PRINT ISSN: 0025-729X ONLINE ISSN: 1326-5377