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Letters

Successful implementation of cardiometabolic monitoring of patients treated with antipsychotics

Debra L Foley, Katherine I Morley, Karyn E Carroll, John Moran, Patrick D McGorry and Brendan P Murphy
MJA 2009; 191 (9): 516-518

To the Editor: A recent article in the Journal describes, again, barriers to implementation of cardiometabolic monitoring among patients prescribed antipsychotic drugs.1 The cardiac health of patients with psychosis is not routinely assessed at first presentation for mental health services, adverse side effects of antipsychotic drugs are not systematically monitored, and patients with treatable risk factors for heart disease are not identified.2

We propose a practical solution to the seemingly intractable problem of implementing guidelines for cardiometabolic monitoring — change the delivery system.

We have employed a general nurse to conduct cardiometabolic monitoring in a pilot study at the Recovery And Prevention of Psychosis Service (RAPPS), a first-episode psychosis service in Melbourne. All 15 eligible patients had their height, weight, blood pressure, waist circumference, fasting total cholesterol, high- and low-density lipoprotein cholesterol, triglycerides and glucose assessed according to national guidelines3 within 1 month of entry to the service, in the hospital, as an outpatient, or in the patient’s home; 14/15 blood samples were taken while the patient was fasting. Very early monitoring (within 7 days of first exposure to antipsychotics) was not implemented for four patients because they were inpatients and judged by ward staff as too unwell to be approached by a general nurse. Future follow-ups will be conducted at 3, 6, 12 and 18 months. Abnormal findings are referred to the treating psychiatrist, who is responsible for ensuring the patient receives appropriate follow-up.

A general nurse can implement clinical guidelines, but this initiative requires substantial planning and ongoing management. Systematic identification of all patients eligible for monitoring requires identification of all pathways into the relevant mental health service, so as to begin monitoring at, or very close to, the point of first exposure to antipsychotics; management tools to track patients over time; and a clinical pathway to track test results and ensure appropriate medical interventions occur when required.

Failure to implement prescribed monitoring guidelines is important because individuals with schizophrenia have a 20% shorter life expectancy than individuals in the general community.4 Side effects of antipsychotic drugs may include dramatic weight gain and elevations in serum cholesterol and glucose levels, which exacerbate the risk for cardiovascular disease. Most early deaths among individuals with schizophrenia are due to cardiovascular disease.5 Failure to monitor cardiovascular health and the adverse side effects of antipsychotic drugs is an important, life-shortening, failure of care.

A simple solution to a complex problem exists if an effective delivery system is used.

Acknowledgements: Debra Foley is supported by the Colonial Foundation, Australia. Katherine Morley is supported by a National Health and Medical Research Council (NHMRC) Post-doctoral Training Fellowship (grant no. 520452). Brendan Murphy holds a Diabetes Australia research grant.

Debra L Foley, Senior Lecturer1Katherine I Morley, Research Fellow1,2Karyn E Carroll, Registered General Nurse1,3John Moran, General Manager1Patrick D McGorry, Executive Director and Professor of Youth Mental Health1Brendan P Murphy, Associate Professor,4 and Clinical Director5

1 Orygen Youth Health Research Centre, University of Melbourne, Melbourne, VIC.

2 Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC.

3 Melbourne Health, Melbourne, VIC.

4 School of Psychology, Psychiatry and Psychological Medicine, Monash University, Melbourne, VIC.

5 Recovery And Prevention of Psychosis Service, Southern Health, Melbourne, VIC.

dfoleyATunimelb.edu.au

  1. Lambert TJ, Newcomer JW. Are the cardiometabolic complications of schizophrenia still neglected? Barriers to care. Med J Aust 2009; 190 (4 Suppl): S39-S42. <eMJA full text> <PubMed>
  2. Parks JJ. Implementing practice guidelines: lessons from public mental health settings. J Clin Psychiatry 2007; 68 Suppl 4: 45-48. <PubMed>
  3. Lambert TJR, Chapman LH; Consensus Working Group. Diabetes, psychotic disorders and antipsychotic therapy: a consensus statement. Med J Aust 2004; 181: 544-548. <eMJA full text> <PubMed>
  4. Hennekens CH. Increasing global burden of cardiovascular disease in general populations and patients with schizophrenia. J Clin Psychiatry 2007; 68 Suppl 4: 4-7. <PubMed>
  5. Lambert TJ, Velakoulis D, Pantelis C. Medical comorbidity in schizophrenia. Med J Aust 2003; 178 (9 Suppl): S67-S70. <eMJA full text> <PubMed>

(Received 29 Apr 2009, accepted 16 Sep 2009)


Timothy J R Lambert

In reply: Foley and colleagues rightly point out that a way to improve the cardiometabolic health of patients with psychosis is to change the way that mental health services are delivered. Although barriers to monitoring exist at the level of the patient, the illness, and the service,1 by focusing too narrowly on the barriers presented by patients, a blaming culture can be perpetuated. If blame is to be attributed, it should be directed towards inflexible services with a medieval belief in separating mental and physical health care.

A number of centres in Australia have started to innovate in service delivery, with structured physical health clinics running in parallel to, and integrated with, mental health clinical programs. Our own centre, the Concord Centre for Cardiometabolic Health in Psychosis (ccCHIP), has been developed to take the notion of integrated care a step further — to actually treat the cardiometabolic abnormalities present. Our model involves a multidisciplinary team comprising psychiatrists, endocrinologists, and dietitians.

However, we believe the potential for broader multidisciplinary input exists, including nurses, pharmacists, psychologists, occupational therapists, social workers and the patient’s general practitioner. It is our philosophy that although detection is the first step to improving the parlous outcomes for our patients, without active intervention, these poor outcomes are unlikely to improve.

Recently, we received funding from the New South Wales Department of Health to develop a more comprehensive plan for education and training, including the production of a manual, to help psychiatric services in NSW develop their own monitoring and intervention services, using ccCHIP as their resource base. This initiative points to the need for government involvement to support these initiatives.

Finally, it is apposite that Foley and colleagues write from the perspective of an early psychosis service — we believe that early detection and intervention for psychosis should be for physical as well as mental health issues.2

Timothy J R Lambert, Professor of Psychological Medicine,1 and Head2

1 Psychological Medicine, Concord Hospital Medical School, University of Sydney, Sydney, NSW.

2 Schizophrenia Treatments and Outcomes, Brain and Mind Research Institute, University of Sydney, Sydney, NSW.

tlambertATmed.usyd.edu.au

  1. Lambert TJ, Newcomer JW. Are the cardiometabolic complications of schizophrenia still neglected? Barriers to care. Med J Aust 2009; 190 (4 Suppl): S39-S42. <eMJA full text><eMJA full text> <PubMed>
  2. Lambert TJ. The medical care of people with psychosis [editorial]. Med J Aust 2009; 190: 171-172. <eMJA full text> <PubMed>

(Received 26 Aug 2009, accepted 16 Sep 2009)


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